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Cancer and various foods
Identifier
006256
Type of Spiritual Experience
Background
A description of the experience
Biochem Pharmacol. 2006 May 14;71(10):1397-421. Epub 2006 Feb 23. Molecular targets of dietary agents for prevention and therapy of cancer. Aggarwal BB, Shishodia S. Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M.D. Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA. aggarwal@mdanderson.org
While fruits and vegetables are recommended for prevention of cancer and other diseases, their active ingredients (at the molecular level) and their mechanisms of action are less well understood.
Extensive research during the last half century has identified various molecular targets that can potentially be used not only for the prevention of cancer but also for treatment. However, lack of success with targeted monotherapy resulting from bypass mechanisms has forced researchers to employ either combination therapy or agents that interfere with multiple cell-signaling pathways.
In this review, we present evidence that numerous agents identified from fruits and vegetables can interfere with several cell-signaling pathways. The agents include
- curcumin (turmeric),
- resveratrol (red grapes, peanuts and berries),
- genistein (soybean),
- diallyl sulfide (allium), S-allyl cysteine (allium), allicin (garlic),
- lycopene (tomato),
- capsaicin (red chilli),
- diosgenin (fenugreek),
- 6-gingerol (ginger),
- ellagic acid (pomegranate),
- ursolic acid (apple, pears, prunes),
- silymarin (milk thistle),
- anethol (anise, camphor, and fennel),
- catechins (green tea),
- eugenol (cloves),
- indole-3-carbinol (cruciferous vegetables),
- limonene (citrus fruits),
- beta carotene (carrots), and dietary fiber.
For instance, the cell-signaling pathways inhibited by curcumin alone include NF-kappaB, AP-1, STAT3, Akt, Bcl-2, Bcl-X(L), caspases, PARP, IKK, EGFR, HER2, JNK, MAPK, COX2, and 5-LOX. The active principle identified in fruit and vegetables and the molecular targets modulated may be the basis for how these dietary agents not only prevent but also treat cancer and other diseases. This work reaffirms what Hippocrates said 25 centuries ago, let food be thy medicine and medicine be thy food.
PMID: 16563357
The source of the experience
PubMedConcepts, symbols and science items
Concepts
Symbols
Science Items
LimoneneActivities and commonsteps
Activities
Overloads
CancerSuppressions
AniseApples
Beans
Beta carotene
Bilberries
Blueberries
Brassicas
Carrots
Chili peppers
Citrus fruits
Cloves
Fennel
Fenugreek
Ginger
Grapes
Milk thistle
Nuts
Onions and garlic
Peanut butter
Pears
Pomegranates
Prunes
Raspberries
Resveratrol
Root vegetables
Soybeans
Strawberries
Tea
Tomatoes
Turmeric