Observations placeholder
Trihexyphenidyl Hydrochloride
Identifier
020235
Type of Spiritual Experience
Background
A description of the experience
Trihexyphenidyl (Artane, Apo-Trihex, Parkin, Pacitane), also known as benzhexol and trihex, is an antiparkinsonian agent of the antimuscarinic class. It has been in clinical usage for decades.
Dose-dependent side effects are frequent. Particularly geriatric patients may react with confusional states or develop delirium.
- Central nervous system: drowsiness, vertigo, headache, and dizziness are frequent. With high doses nervousness, agitation, anxiety, delirium, and confusion are noted. Trihexyphenidyl may be abused due to a short acting mood-elevating and euphoriant effect. The normal sleep architecture may be altered (REM sleep depression). Trihexyphenidyl may lower the seizure-threshold.
- Peripheral side effects: blurred vision, dry mouth, impaired sweating, abdominal discomfort, and constipation are frequent. Tachycardia may be noted. Allergic skin reactions may occur. Parenteral use may cause orthostatic hypotension.
- Eyes: trihexyphenidyl causes mydriasis with or without photophobia. It may precipitate narrow angle glaucoma.
- Tolerance may develop during therapy which requires dose adjustments.
On Feb, 1, 2016: 351 people reported to have side effects when taking Trihexyphenidyl hydrochloride. Among them, 20 people (5.70%) have Hallucination.
On Feb, 4, 2016: 351 people reported to have side effects when taking Trihexyphenidyl hydrochloride. Among them, 8 people (2.28%) have Death.
Time on Trihexyphenidyl hydrochloride when people have Death :
< 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
Death | 0.00% | 0.00% | 0.00% | 100.00% | 0.00% | 0.00% | 0.00% |