Observations placeholder
Tannin inhibits HIV-1 entry by targeting gp41
Identifier
017820
Type of Spiritual Experience
Background
A description of the experience
Acta Pharmacol Sin. 2004 Feb;25(2):213-8.
Tannin inhibits HIV-1 entry by targeting gp41.
Lü L1, Liu SW, Jiang SB, Wu SG.
- 1Institute of Pharmaceutical Sciences of the First Medical University of PLA, Key Lab of GD for Screening of New Drug, Guangzhou, Guangdong 510515, China.
AIM:
To investigate the mechanism by which tannin inhibits HIV-1 entry into target cells.
METHODS:
The inhibitory activity of tannin on HIV-1 replication and entry was detected by p24 production and HIV-1-mediated cell fusion, respectively. The inhibitory activity on the gp41 six-helix bundle formation was determined by an improved sandwich ELISA.
RESULTS:
Tannins from different sources showed potent inhibitory activity on HIV-1 replication, HIV-1-mediated cell fusion, and the gp41 six-helix bundle formation.
CONCLUSION:
Tannin inhibits HIV-1 entry into target cells by interfering with the gp41 six-helix bundle formation, thus blocking HIV-1 fusion with the target cell.
PMID:
14769212