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Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L
Identifier
018909
Type of Spiritual Experience
Background
A description of the experience
Molecules. 2015 Sep 10;20(9):16375-87. doi: 10.3390/molecules200916375.
Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
Lei X1, Li J2, Liu B3, Zhang N4, Liu H5.
- 1Basic research department of Jiamusi College, Heilongjiang University of Chinese Medicine, No. 39 Guang Hua Street, Qian Jin District, Jia Mu Si 154100, China. leixia2006@163.com.
- 2Basic research department of Jiamusi College, Heilongjiang University of Chinese Medicine, No. 39 Guang Hua Street, Qian Jin District, Jia Mu Si 154100, China. jmsxyrsk@163.com.
- 3Basic research department of Jiamusi College, Heilongjiang University of Chinese Medicine, No. 39 Guang Hua Street, Qian Jin District, Jia Mu Si 154100, China. liubin169@163.com.
- 4Basic research department of Jiamusi College, Heilongjiang University of Chinese Medicine, No. 39 Guang Hua Street, Qian Jin District, Jia Mu Si 154100, China. zhangning345678@163.com.
- 5Basic research department of Jiamusi College, Heilongjiang University of Chinese Medicine, No. 39 Guang Hua Street, Qian Jin District, Jia Mu Si 154100, China. haiyangliu2015@163.com.
Abstract
The Portulaca oleracea L. (P. oleracea) has been used to treat bacillary dysentery for thousands of years in China.
Pharmacology studies on P. oleracea have also showed its significant antibacterial effects on the enteropathogenic bacteria, which might reveal the treatment of P. oleracea in cases of bacillary dysentery to some extent.
To date, however, the therapeutic basis of P. oleracea treating on bacillary dysentery remains unknown. We determined the antibacterial effective fraction of P. oleracea in a previous study. The current study, which is based on our previous study, was first designed to isolate, identify and screen antibacterial active constituents from P. oleracea. As a result, four new compounds
- (1-4), portulacerebroside B (1),
- portulacerebroside C (2),
- portulacerebroside D (3) and
- portulaceramide A (4)
along with five known compounds (5-9) were isolated, and structures were established by their physico-chemical constants and spectroscopic analysis.
The antibacterial activities against common enteropathogenic bacteria were evaluated for all compounds and the new compounds 1-4 showed significant antibacterial effect on enteropathogenic bacteria in vitro, which might contribute to revealing the treatment of P. oleracea in cases of bacillary dysentery.
KEYWORDS:
Portulaca oleracea L.; antibacterial activity; ceramides; cerebrosides; enteropathogenic bacteria
PMID:
26378504