Observations placeholder
Radiation-induced inflammation and autoimmune diseases
Identifier
029355
Type of Spiritual Experience
None
Background
Mil Med Res. 2018; 5: 9.
Published online 2018 Mar 20. doi: 10.1186/s40779-018-0156-7
PMCID: PMC5859747
PMID: 29554942
Rasoul Yahyapour,1 Peyman Amini,2 Saeed Rezapour,2 Mohsen Cheki,3 Abolhasan Rezaeyan,4 Bagher Farhood,5 Dheyauldeen Shabeeb,6,7 Ahmed Eleojo Musa,8 Hengameh Fallah,9 and Masoud Najafi 10
1School of Medicine, Jiroft University of Medical Sciences, Jiroft, Zip code: 8813833435 Iran
2Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran, Zip code: 1417613151 Iran
A description of the experience
Radiation-induced inflammation and autoimmune diseases
Although there is a long way to illustrate the complete mechanisms of IR-induced diabetes and thyroid diseases, recent studies suggest that the chronic upregulation of inflammatory mediators and cytokines play a key role. It is feasible that long-term exposure to a high level of some cytokines, particularly IL-1β and IFN-γ, can disrupt the normal function of thyrocytes in the thyroid, as well as beta cells in the pancreas. However, it is likely that genetic background plays a key role in the appearance of autoimmune diseases. Although there is no suggested strategy for the prevention or reduction of autoimmune diseases following exposure to IR during radiotherapy or radiation accidents, there may be several solutions, such as the administration of radioprotectors, anti-inflammatory agents, or radiation mitigators. However, to date, there is no evidence to confirm this idea.
The source of the experience
PubMedConcepts, symbols and science items
Concepts
Symbols
Science Items
Activities and commonsteps
Activities
Overloads
Autoimmune diseasesCancer
Diabetes
Diabetes mellitus
Pancreatic cancer
Radiation
Thyroid disease