Observations placeholder
Oseltamivir and flu
Identifier
005585
Type of Spiritual Experience
Background
There may be amongst the ‘flu patients who have experienced hallucinations some who actually had flu and whose hallucinations were caused by very high temperatures, high temperature is normal with ‘flu and hyperthermia not uncommon. There is a separate section devoted to Hyperthermia. But hyperthermia does not account for all the figures, as is evident from the research
In this case I think we have the clue in the research – the cause was overdose and may have resulted in a toxic effect. But it appears that some research has shown the flu antivirals to be toxic to the liver in general, increasing chloresterol and also damaging various necessary functions of the liver….
Potential adverse effects of oseltamivir in rats: males are more vulnerable than females. El-Sayed WM, Al-Kahtani MA - King Faisal University, Faculty of Science, Department of Biological Sciences, Al-Hufof 31982, Ahsaa, KSA.
Oseltamivir is the most widely used antiviral drug for the treatment and prophylaxis of influenza. However, not much is known about its adverse effects.
The potential side effects were investigated in male and female rats (140-170 g). Oseltamivir was administered at 2.2 mg·kg(-1)·day(-1) for 5 days. For both genders, treatment with oseltamivir resulted in significant reductions in the hepatic activities of glutathione reductase, glutathione peroxidase, and glutathione S-transferase. Also for both genders, oseltamivir produced modest reductions in the hepatic activities of UDP-glucuronosyltransferase, quinone oxidoreductase, thioredoxin reductase, CYP1A1/2, and CYP3A, as well as hepatic glutathione content. For both genders, neither the kidney functions nor protein profile was affected by oseltamivir. Oseltamivir also caused significant elevation in serum levels of both triacylglycerols and LDL-cholesterol and in the activity of γ-glutamyl transpeptidase, in both genders. For male animals only, oseltamivir treatment elevated the serum level of total cholesterol as well as the activity of serum alanine aminotransferase, and reduced the hepatic activities of superoxide dismutase and catalase.
Oseltamivir caused oxidative stress and acute toxicity in the liver, and disrupted the cholesterol and lipid metabolism but was less likely to cause serious drug interactions. There was a sexual differentiation in these adverse effects, with adverse effects being more evident in male rats.
A description of the experience
Possible neuropsychiatric reaction to high-dose oseltamivir during acute 2009 H1N1 influenza A infection - Nakamura K, Schwartz BS, Lindegårdh N, Keh C, Guglielmo BJ.; School of Medicine, University of California, San Francisco, California, USA.
The safety of high-dose oseltamivir during treatment of 2009 H1N1 influenza A infection for critically ill patients is unknown. Here we report on a case patient with severe, delayed-onset neuropsychiatric symptoms after administration of high-dose oseltamivir. Clinicians should be vigilant to the possible increased risk of complications associated with high-dose oseltamivir therapy for 2009 H1N1 influenza A infection.