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Nalbuphine is a semi-synthetic opioid used commercially as an analgesic under a variety of trade names, including Nubain and Manfine.

Nalbuphine is used for the relief of moderate to severe pain. It is also be used as a supplement to balanced anesthesia, for preoperative and postoperative analgesia, and for obstetrical analgesia during labor and delivery.

As reported in the current Nubain Package Insert (2005), the most frequent side effect in 1066 patients treated with nalbuphine was sedation in 381 (36%).

Other, less frequent reactions are: feeling sweaty/clammy 99 (9%), nausea/vomiting 68 (6%), dizziness/vertigo 58 (5%), dry mouth 44 (4%), and headache 27 (3%). Other adverse reactions which may occur  are:

• CNS effects: Nervousness, depression, restlessness, crying, euphoria, floating, hostility, unusual dreams, confusion, faintness, hallucinations, dysphoria, feeling of heaviness, numbness, tingling, unreality. The incidence of psychotomimetic effects, such as unreality, depersonalization, delusions, dysphoria and hallucinations has been shown to be less than that which occurs with pentazocine.
• Cardiovascular: Hypertension, hypotension, bradycardia, tachycardia, pulmonary edema.
• Gastrointestinal: Cramps, dyspepsia, bitter taste.
• Respiration: Depression, dyspnea, asthma.
• Dermatological: Itching, burning, urticaria.
• Obstetric: Pseudo-sinusoidal fetal heart rhythm.

Other possible, side effects include speech difficulty, urinary urgency, blurred vision, flushing and warmth.

On Jan, 21, 2016: 43 people reported to have side effects when taking Nalbuphine hydrochloride. Among them, 2 people (4.65%) have Hallucination.

On Jan, 21, 2016: 396 people reported to have side effects when taking Nalbuphine. Among them, 6 people (1.52%) have Hallucination.