Observations placeholder
Methyldopa, Aldoril, Dopamet
Identifier
017952
Type of Spiritual Experience
Background
A description of the experience
Methyldopa (L-α-Methyl-3,4-dihydroxyphenylalanine; Aldomet, Aldoril, Dopamet, Dopegyt, etc.) is an alpha-adrenergic agonist (selective for α2-adrenergic receptors) psychoactive drug used as a sympatholytic or antihypertensive. Its use is now mostly deprecated following the introduction of alternative safer classes of agents. However, it continues to have a role in otherwise difficult to treat hypertension and gestational hypertension (previously known as pregnancy-induced hypertension (PIH)).
Methyldopa is capable of inducing a number of adverse side effects, which range from mild to severe. Nevertheless, they are generally mild when the dose is less than 1 gram per day.[2] Side effects may include:
- Psychological
- Depression and/or even suicidal ideation, as well as nightmares
- Apathy and/or anhedonia, as well as dysphoria
- Anxiety, especially of the social anxiety variant
- Decreased alertness, awareness, and wakefulness
- Impaired attention, focus, and concentration
- Decreased desire, drive, and motivation
- Fatigue or lethargy and/or malaise or lassitude
- Sedation or drowsiness and/or somnolence or sleepiness
- Agitation or restlessness
- Cognitive and memory impairment
- Derealization and/or depersonalization, as well as mild psychosis
- Sexual dysfunction including impaired libido, desire, and drive
Physiological
- Dizziness, lightheadedness, or vertigo
- Miosis or pupil constriction
- Xerostomia or dry mouth
- Gastrointestinal disturbances such as diarrhea and/or constipation
- Headache or migraine
- Myalgia or muscle aches, arthralgia or joint pain, and/or paresthesia ("pins and needles")
- Restless legs syndrome (RLS)
- Parkinsonian symptoms such as muscle tremors, rigidity, hypokinesia, and/or balance or postural instability
- Akathisia, ataxia, dyskinesia as well as even tardive dyskinesia, and/or dystonia
- Bell's palsy or facial paralysis
- Sexual dysfunction consisting of impaired erectile dysfunction and/or anorgasmia
- Hyperprolactinemia or excess prolactin, gynecomastia/breast enlargement in males, and/or amenorrhoea or absence of menstrual cycles in females
- Bradycardia or decreased heart rate
- Hypotension or decreased blood pressure (though this may also be considered a therapeutic benefit)
- Orthostatic hypotension (also known as postural hypotension)
- Hepatitis, hepatotoxicity, or liver dysfunction or damage
- Pancreatitis or inflammation of the pancreas
- Haemolytic anaemia or deficiency in red blood cells (RBCs)
- Myelotoxicity or bone marrow suppression, potentially leading to thrombocytopenia or blood platelet deficiency and/or leukopenia or white blood cell (WBC) deficiency
- Hypersensitivity such as lupus erythematosus, myocarditis, and/or pericarditis
- Lichenoid reactions such as skin lesions and/or rashes
- Pallor
On Sep, 13, 2015: 1,893 people reported to have side effects when taking Methyldopa. Among them, 19 people (1.00%) have Hallucination.
On Sep, 28, 2015: 1,894 people reported to have side effects when taking Methyldopa. Among them, 19 people (1.00%) have Death.
Time on Methyldopa when people have Death :
< 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
Death | 100.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
On Sep, 13, 2015: 1,637 people reported to have side effects when taking Aldomet. Among them, 20 people (1.22%) have Hallucination.
Time on Aldomet when people have Hallucination :
< 1 month | 1 - 6 months | 6 - 12 months | 1 - 2 years | 2 - 5 years | 5 - 10 years | 10+ years | |
Hallucination | 88.24% | 11.76% | 0.00% | 0.00% | 0.00% | 0.00% | 0.00% |
On Sep, 29, 2015: 1,637 people reported to have side effects when taking Aldomet. Among them, 26 people (1.59%) have Death.