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Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis
Identifier
020877
Type of Spiritual Experience
Background
A description of the experience
Phytochemistry. 2015 Aug;116:253-61. doi: 10.1016/j.phytochem.2015.03.009. Epub 2015 Apr 13.
Isolation and anti-hepatitis B virus activity of dibenzocyclooctadiene lignans from the fruits of Schisandra chinensis.
Xue Y1, Li X2, Du X3, Li X3, Wang W3, Yang J3, Chen J3, Pu J4, Sun H5.
- 1State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China.
- 2Chemical Biology Research Center, Yanbian University, Yanji 133002, PR China.
- 3State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China.
- 4State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address: pujianxin@mail.kib.ac.cn.
- 5State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. Electronic address: hdsun@mail.kib.ac.cn.
Abstract
Seven lignans with a dibenzocyclooctadiene skeleton, termed schinlignans A-G, and a 6,7-seco-homolignan, schischinone, together with seven known lignans, were isolated from the fruits of Schisandra chinensis (Turcz.) Baill. Their structures were elucidated by extensive spectroscopic methods, including HRESIMS, IR, UV, and 2D NMR (COSY, HMQC, COSY, and HMBC experiments). The stereochemistry at the chiral centers and the biphenyl moiety, were determined using ROESY, as well as via interpretation of their ECD spectra. Schinlignan G and methylgomisin O exhibited potent anti-hepatitis B virus activity against HBV DNA replication with IC50 values of 5.13 and 5.49μgmL(-1), respectively.
Copyright © 2015 Elsevier Ltd. All rights reserved.
KEYWORDS:
6,7-Seco-homolignan; Dibenzocyclooctadiene lignans; Hepatitis B virus; Schisandra chinensis; Schisandraceae
PMID:
25882501