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In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica
Identifier
021156
Type of Spiritual Experience
Background
A description of the experience
Am J Chin Med. 2003;31(2):225-34.
In vitro cytotoxic, antiviral and immunomodulatory effects of Plantago major and Plantago asiatica.
Chiang LC1, Chiang W, Chang MY, Lin CC.
- 1Graduate Institute of Medicine, Kaohsiung Medical University, Taiwan, ROC.
Abstract
Plantago major linn. and P. asiatica Linn. (Plantaginaceae) are commonly used as folk medicine in Taiwan for treating infectious diseases related to the respiratory, urinary and digestive tracts. In this study, we investigated the antiviral, cytotoxic and immunomodulatory activities of hot water extracts of these two species in vitro on a series of viruses, namely herpesviruses (HSV-1 and HSV-2), adenoviruses (ADV-3, ADV-8 and ADV-11), and on various human leukemia, lymphoma and carcinoma cells with XTT, BrdU and IFN-gamma kits. Results showed that hot water extract of P. asiatica possessed significant inhibitory activity on the proliferation of lymphoma (U937) and carcinoma (bladder, bone, cervix, kidney, lung and stomach) cells and on viral infection (HSV-2 and ADV-11). P. major and P. asiatica both exhibited dual effects of immunodulatory activity, enhancing lymphocyte proliferation and secretion of interferon-gamma at low concentrations (< 50 microg/ml), but inhibiting this effect at high concentration (> 50 microg/ml). The present study concludes that hot water extracts of P. major and P. asiatica possess abroad-spectrum of antileukemia, anticarcinoma and antiviral activities, as well as activities which modulate cell-mediated immunity. Further investigations to elucidate the active component(s) of P. asiatica and P. major and to evaluate their clinical application are warranted.
PMID:
12856861
The source of the experience
PubMedConcepts, symbols and science items
Concepts
Symbols
Science Items
Activities and commonsteps
Activities
Overloads
Adenovirus infectionAntivirals
Bladder and urinary tract disease
Cancer
Herpes simplex
Intestine disease
Leukemia
Lung disease
Stomach disease