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Dr Duke's list of Chemicals and their Biological Activities in: Mitragyna speciosa KORTH. (Rubiaceae) -- Kratum
Identifier
019179
Type of Spiritual Experience
Background
A description of the experience
Chemicals and their Biological Activities in: Mitragyna speciosa KORTH. (Rubiaceae) -- Kratum
Chemicals
3-DEHYDROMITRAGYNINE Leaf 36 ppm; DUKE1992A
No activity reported.
AJMALICINE Leaf: DUKE1992A
Adrenolytic HH2 ; Antiadrenergic WOI ; Antiaggregant EMP5:344 ; Antidiuretic HDN ; Antihypertensive JBH ; Cerebrocirculant JBH ; Circulotonic HDN ; CNS-Depressant; Hypotensive HH2 ; Sympatholytic HH2 ; Tranquilizer JBH
CORYNANTHEIDALINE Leaf: DUKE1992A
No activity reported.
CORYNANTHEIDINE Leaf: DUKE1992A
No activity reported.
EPICATECHIN Leaf 150 ppm; DUKE1992A
Allelochemic IC100=1 mM 438 ; Anabolic X16028976 ; Antiaggregant IC94=200 ug/ml PR13:597 ; Antianaphylactic; Antibacterial MIC=>1,000 ug/ml; Anticomplementary 1/2 aspirin PM57:A48 ; Antidiabetic 30 mg/kg rat; AntiEBV EMP6:189 ; Antifeedant JCE27:251 ; Antihepatitic V&D ; AntiHIV EC50=2 ug/ml POP:270 ; Antihyperglycemic; Antiinflammatory; Antileukemic IC50=>10 ug/ml; Antilipoperoxidant PR13:597 ; Antimutagenic; Antioxidant 2.5 x Vit. E BO2 3/4 quercetin JAF49:3653 IC50=10.2 uM PR14:501 IC50=6.3 ug/ml CPB38:1049 ; Antiperoxidant JBH ; Antiviral; Cancer-Preventive 525 ; Cardiotonic DUKE1992B ; Choline-Sparing AFR27:149 ; Hepatotropic DUKE1992B ; Hypocholesterolemic AFR27:149 ; Hypoglycemic DUKE1992B ; Insulinogenic EMP6:170 ; Interleukin-1-alpha-Inhibitor X16248545 ; Interleukin-6-mRNA-Inhibitor X16248545 ; Lipoxygenase-Inhibitor IC50=140 uM PCF IC97=5 mM JAF38:688 ; NO-Inhibitor X16248545 ; Pancreatogenic DUKE1992B ; Peroxynitrite-Scavenger IC50=0.181 ug/ml JAF48:5768 ; Pesticide DUKE1992B ; Propecic PH2 ; TNF-alpha-Inhibitor X16248545 ; Xanthine-Oxidase-Inhibitor IC50=>40
ISOMITRAFOLINE Plant: DUKE1992A
No activity reported.
ISOMITRAPHYLLINE Leaf: DUKE1992A
Antileukemic IC50=45-60 uM/l PM59:A583 ; Immunostimulant PAT.4,844,901 ; Phagocytotic
ISOSPECIOFOLINE Plant: DUKE1992A
No activity reported.
MITRACILIATINE Leaf 32 ppm; DUKE1992A
No activity reported.
MITRAGYNALINE Leaf: DUKE1992A
No activity reported.
MITRAGYNINE Leaf 86 ppm; DUKE1992A
Analgesic W&W ; Anesthetic DUKE1992B ; CNS-Stimulant DUKE1992B ; Hypotensive DUKE1992B ; Myorelaxant DUKE1992B ; Vasodilator DUKE1992B
MITRAGYNOL Plant: DUKE1992A
No activity reported.
MITRAPHYLLINE Leaf: DUKE1992A
Anesthetic IWU ; Antihypertensive IWU ; Antileukemic IC50=60-120 uM/l PM59:A583 ; Cardiodepressant IWU ; CNS-Depressant JBH ; Hypotensive JBH ; Immunostimulant PAT.4,844,901 ; Myocontractant IWU ; Myorelaxant DUKE1992B ; Pesticide DUKE1992B ; Protisticide IWU ; Vasodilator DUKE1992B
MITRASPECINE Seed: DUKE1992A
No activity reported.
MITRAVERSINE Plant: DUKE1992A
No activity reported.
PAYNANTHEINE Leaf 50 ppm; DUKE1992A
No activity reported.
RHYNCHOPHYLLINE Leaf: DUKE1992A
Anesthetic IWU ; Antiaggregant PH2 ; Antidementia X12895681 ; Antiexcitotoxic X12895681 ; Antihypertensive; Antiischemic X12895681 ; Antioxidant X12895681 ; Antipyretic JBH ; Antiradicular X12895681 ; Antithrombotic PH2 ; Calcium-Antagonist 10.1 uM rat M18481 ; Calcium-Blocker X12546715 ; Cardiodepressant IWU ; Dopaminergic PH2 ; Febrifuge PJB1(2):284 ; Hypotensive; Myocontractant IWU ; Neuroparalytic DUKE1992B ; Protisticide IWU ; Sedative DUKE1992B ; Serotonergic PH2 ; Uterotonic DUKE1992B ; Vasodilator X14668978
ROTUNDIFOLINE Plant: DUKE1992A
No activity reported.
SPECIOCILIATINE Leaf 30 ppm; DUKE1992A
Analgesic DUKE1992B ; Antitussive DUKE1992B
SPECIOFOLINE Leaf: DUKE1992A
No activity reported.
SPECIOGYNINE Leaf 44 ppm; DUKE1992A
No activity reported.
SPECIOPHYLLINE Leaf: DUKE1992A
Antileukemic IC50=60 uM/l PM59:A583
STIPULATINE Leaf: DUKE1992A
No activity reported.
UNCARINE-D Plant: DUKE1992A
Cytotoxic ED50=36 526
The source of the experience
Dr Dukes plant databaseConcepts, symbols and science items
Concepts
Symbols
Science Items
Activities and commonsteps
Commonsteps
References
438: Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.
525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
526: Collins, D.J., Culvenor, C.C.J., Lamberton, J.A., Loder, J.W. and Price, J.R., Plants for Medicines, CSIRO, East Melbourne, Australia, 1990, 303 pp.
AFR27:149: Singleton, V.L. 1981. Naturally Occurring Food Toxicants: Phenolic Substances of Plant Origin Common in Foods. Advances in Food Research 27: 149-217.
BO2: Jim Duke's personal files
CPB38:1049: Uchida, U., Ohta, H., Niwa, M., Mori, A., Nonaka, G-i., Nishioka, I., and Zaki, M. 1989. Prolongation of Life Span of Stroke-Prone Spontaneously Hypertensive Rats (SHRSP) Ingesting Persimmon Tannin. Chem. Pharm. Bull. 38(4): 1049-1052, 1990.
DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.
DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.
EMP5:344: Jim Duke's personal files
EMP6:170: Economic & Medicinal Plant Research, 6: 170.
EMP6:189: Economic & Medicinal Plant Research, 6: 189.
HDN: Neuwinger, H. D. 1996. African Ethnobotany - Poisons and Drugs. Chapman & Hall, New York. 941 pp.
HH2: Hansel, R., Keller, K., Rimpler, H., and Schneider, G. eds. 1992. Hager's Handbuch der Pharmazeutischen Praxis, Drogen (A-D), 1209 pp., 1993 (E-O), 970 pp., 1994 (P-Z), 1196 pp. Springer-Verlag, Berlin.
IWU: Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
JAF38:688: Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.
JAF48:5768: Jim Duke's personal files
JAF49:3653: Jim Duke's personal files
JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
JCE27:251: Jim Duke's personal files
M18481: Jim Duke's personal files
PAT.4,844,901: Jim Duke's personal files
PCF: Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.
PH2: Jim Duke's personal files
PJB1(2):284: Jim Duke's personal files
PM57:A48: Jim Duke's personal files
PM59:A583: Jim Duke's personal files
POP:270: Jim Duke's personal files
PR13:597: Jim Duke's personal files
PR14:501: Jim Duke's personal files
V&D: Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
W&W: Wagner & Wolff, eds. 1977. New Natural Products (RS164. I56. 176)
WOI: ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.
X12546715: Jim Duke's personal files
X12895681: Jim Duke's personal files
X14668978: Jim Duke's personal files
X16028976: Jim Duke's personal files
X16248545: Jim Duke's personal files
ppm = parts per million
tr = trace