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Chemical composition and antibacterial activities of Illicium verum against antibiotic-resistant pathogens
Identifier
021098
Type of Spiritual Experience
Background
A description of the experience
J Med Food. 2010 Oct;13(5):1254-62. doi: 10.1089/jmf.2010.1086.
Chemical composition and antibacterial activities of Illicium verum against antibiotic-resistant pathogens.
Yang JF1, Yang CH, Chang HW, Yang CS, Wang SM, Hsieh MC, Chuang LY.
- 1Department of Chemical Engineering, I-Shou University, Kaohsiung, Taiwan.
Abstract
In recent years, human pathogenic microorganisms have developed multiple drug resistance and caused serious nosocomial infections. In this study, we identified four new antimicrobial compounds from the Chinese herbal medicine Illicium verum and assessed their antibacterial efficacies.
The supercritical CO₂ and ethanol extracts of Illicium verum showed substantial antibacterial activity against 67 clinical drug-resistant isolates, including
- 27 Acinetobacter baumannii,
- 20 Pseudomonas aeruginosa, and
- 20 methicillin-resistant Staphylococcus aureus.
The diethyl ether (EE) fraction obtained from partition extraction and supercritical CO₂ extracts revealed an antibacterial activity with a minimum inhibitory concentration value of 0.15-0.70 mg/mL and 0.11 mg/mL, respectively. The EE fraction of I. verum showed synergetic effects with some commercial antibiotics.
The antimicrobial mechanism was investigated with killing curves and scanning electron microscopy observation. The chemical components of the extracts were analyzed by spectrophotometry; (E)-anethole, anisyl acetone, anisyl alcohol, and anisyl aldehyde exhibited antibacterial activity against different clinical isolates. These extracts from I. verum can be further developed into antibiotic medicines due to their proven antibacterial activity.
PMID: 20828316
The source of the experience
PubMedConcepts, symbols and science items
Concepts
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Science Items
Activities and commonsteps
Activities
Overloads
AntibioticsBacterial infection
Pseudomonas aeruginosa infection
Staphylococcal infection