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Cancer prevention by natural compounds
Identifier
017699
Type of Spiritual Experience
Background
A description of the experience
Drug Metab Pharmacokinet. 2004 Aug;19(4):245-63.
Cancer prevention by natural compounds.
Tsuda H1, Ohshima Y, Nomoto H, Fujita K, Matsuda E, Iigo M, Takasuka N, Moore MA.
- 1Department of Molecular Toxicology, Nagoya City University Graduate School of Medical Sciences, Japan. htsuda@med.nagoya-cu.ac.jp
Abstract
Increasing attention is being paid to the possibility of applying cancer chemopreventive agents for individuals at high risk of neoplastic development. For this purpose by natural compounds have practical advantages with regard to availability, suitability for oral application, regulatory approval and mechanisms of action.
Candidate substances such as phytochemicals present in foods and their derivatives have been identified by a combination of epidemiological and experimental studies.
Plant constituents include vitamin derivatives, phenolic and flavonoid agents, organic sulfur compounds, isothiocyanates, curcumins, fatty acids and d-limonene. Examples of compounds from animals are unsaturated fatty acids and lactoferrin.
Recent studies have indicated that mechanisms underlying chemopreventive potential may be combinations of anti-oxidant, anti-inflammatory, immune-enhancing, and anti-hormone effects, with modification of drug-metabolizing enzymes, influence on the cell cycle and cell differentiation, induction of apoptosis and suppression of proliferation and angiogenesis playing roles in the initiation and secondary modification stages of neoplastic development.
Accordingly, natural agents are advantageous for application to humans because of their combined mild mechanism. Here we review naturally occurring compounds useful for cancer chemprevention based on in vivo studies with reference to their structures, sources and mechanisms of action.
PMID: 15499193
The source of the experience
PubMedConcepts, symbols and science items
Concepts
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Activities and commonsteps
Activities
Overloads
CancerSuppressions
CurcuminEating for health
Limonene
Sulphur
Vitamin A
Vitamin B1
Vitamin B12
Vitamin B2
Vitamin B3
Vitamin B5
Vitamin B6
Vitamin B7
Vitamin B9
Vitamin C
Vitamin D
Vitamin E
Vitamin K